Effect of Ginkgo biloba extract on cerebral ischemia during early stage of subarachnoid hemorrhage in rats |
| |
Authors: | SUN Bao-liang XIA Zuo-li YANG Ming-feng GE Bao-lin |
| |
Institution: | 1. Institute of Microcirculation, Affiliated Hospital, Taishan Medical College, Taian 271000, China;
2. Department of Pathophysiology, Medical College of Qingdao University, Qingdao 266021,China |
| |
Abstract: | AIM: To investigate the effect of Ginkgo biloba extrac (GBE) on cerebral ischemia during early stage of subarachnoid hemorrhage (SAH). METHODS: Noncraniotomy models of SAH in Wistar rats were used and animals were divided into sham-operated group, SAH group and SAH+GBE group. Dynamic change of regional cerebral blood flow (rCBF) was detected. Brain endothelin-1(ET-1) and calcium contents were also determined at different time point during 24 hours after the operation. Pathological change of neurons of hippocampus CA1 region was observed. RESULTS: In SAH group, rCBF decreased immediately and persistently after induction of SAH. Values of brain ET-1 content and calcium content at 1 hour, 6 hours and 24 hours were significantly higher than those in sham-operated group. Neurons of hippocampus CA1 region were damaged severely 3 days after onset of SAH. Above abnormal changes in SAH+GBE group were much slighter than those in SAH group. CONCLUSION: GBE may relieve cerebral ischemic damage after SAH. |
| |
Keywords: | Subarachnoid hemorrhage Cerebral ischemia Endothelins Rats |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|