Hypertonic NaCl-NaAc improves the microcirculation in rats subjected to hemorrhagic shock |
| |
Authors: | ZHOU Xue-wu HU De-yao LIU Liang-ming ZHAO Ke-sen Huang Zhu-hai ZHU Zuo-jiang |
| |
Affiliation: | 1. Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China; 2. Department of Pathophysiology, First Militray Medical University, Guangzhou 510515, China |
| |
Abstract: | AIM: To study the effects of hypertonic NaCl-NaAc on microcirculation in hemorrhage-shocked rats.METHODS: SD rats were randomized into three groups of 7.5% NaCl(hypertonic saline, HS), 5% NaCl-3.5% NaAc(hypertonic sodium acetate, HSA) and 0.9% NaCl(normal saline, NS). 4 mL/kg HS, HSA or NS was given intravenously following hemorrhagic shock. The microcirculation of spinotrapezius muscle was observed.RESULTS: HS increased mean aortic pressure more significant than HSA. Variables including arteriolar and venular diameter, velocity and volumetric flow rate and open capillaries were increased and erythrocyte aggregation was decreased in 5 min after resuscitation with both HS and HSA solutions.5 min later, variables were deteriorated in HS group.After local treatment, arteriolar and venular diameters were dilated significantly in HSA group.CONCLUSION:HSA had superior effects to HS in improving microcirculation of hemorrhage-shocked rats. |
| |
Keywords: | Saline solution hypertonic Actic acids Shock hemorrhagic Microcirculation |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
|
点击此处可从《园艺学报》下载全文 |
|