Dynamic expression of CD30 on peripheral blood lymphocytes in mice after a cecal ligation and puncture |
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Authors: | CHEN Li-ping YAN Liang YANG Hao-zhuang ZHANG Sui-mei |
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Affiliation: | Department of Pathophysiology, Medical College of Jinan University, Guangzhou 510632, China |
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Abstract: | AIM: To investigate the details of Th2 cell differentiation in septic mice. METHODS: Experimental septic mice were induced by cecal ligation and puncture (CLP). The exression of CD30 on CD4+T cells at different time after CLP were estimated by flow cytometry following three-color immunofluorescent staining.RESULTS: CD30 expression on CD4+T cell was different at each time point. The highest expression was showed at 38 h after CLP and declined later, which matched the changes in mortality of the animals. CONCLUSION: During sepsis, differentiation of Th2 cell changed with the development of sepsis and might be associated with the severity of the disease. |
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Keywords: | Sepsis Lymphocytes Antigens CD30 Flow cytometry Mice |
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