Effects of glucose and Mg2+ in the neurons damaged by glutamate |
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| Authors: | XING Hong HE Qi-hua YUAN Lan XU Jia-ling WU Ben-jie |
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| Institution: | 1. Department of Biophysics,Beijing Medical University, Beijing 100083, China;
2. Analysis Center of Medicine and Pharmacy, Beijing Medical University, Beijing 100083, China |
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| Abstract: | AIM and METHODS: To observe the effects of glucose-free and Mg2+-free in the extracellular fluid on the changes of Ca 2+]i in the cerebro-cortical neurons damaged by 1mmol/L glutamate using laser confocal scanning microscope. RESULTS: Both frequency and amplitude of neuronal calcium oscillation induced by glutamate were lowered in glucose-free and Mg2+-free buffers. The basic Ca2+]i concentration was lowered in the former case , but it was elevated in the latter case. CONCLUSION: Mg2+-free aggravates Ca2+]i overload induced by 1mmol/L glutamate ,under certain conditions the glucose-free might resist damage role of glutamate and Mg2+-free. |
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| Keywords: | Glutamates Glucose Magnesium Calcium |
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