Homocysteine induces metallothionein formation in mice |
| |
| Authors: | LI Shu-lian LI Zai-quan ZHANG Ying XUE Lin XU Song WANG Xiao-hong TANG Chao-shu |
| |
| Institution: | 1. Laboratory Center, the First Hospital, Beijing Medical University, Beijing 100034, China; 2. Department of Pathophysiology, Kaifeng Medical College, Kaifeng 475001, China |
| |
| Abstract: | AIM: To observe the changes of metallothionein (MT) in various tissues of mice during hyperhomocysteinemia. METHODS: Intraperitoneal injection of homocysteine into mice induced hyperhomocysteinemia. The contents of tissue MT and malondialdehyde (MDA) in liver, heart and kidney were determined. RESULTS: Compared with control group, tissue MT levels in Hcy-group animals were increased by 210% (P＜0.01) for liver, by 133% (P＜0.05) for heart and by 60% (P＜0.01) for kidney. Tissue MDA contents were increased by 6%, 52%(P＜0.05) and 69% (P＜0.05), respectively. However, in treated animals with Hcy plus superoxide dismutase (SOD), the tissue MT contents in liver, heart and kidney were decreased by 22% (P＜0.05), 33% (P＜0.05) and 13% (P＞0.05), respectively, compared with Hcy alone group. Tissue MDA contents were decreased by 24% (P＜0.05), 21% (P＜0.05) and 48% (P＜0.01). There was a positive correlation between tissue MT content and MDA level. CONCLUSION: Hcy could induce tissue MT formation through oxidative stress. |
| |
| Keywords: | Homocysteine Metallothionein Stress |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|
