Role of K+ channels in hypoxic pulmonary vasoconstriction in normal and chronic hypoxic rats |
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| Authors: | JIN Si WANG Di-xun SUN Bing-yong |
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| Institution: | 1. Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Pulmonary Disease Laboratry of Ministry of Health of China, Wuhan 430030, China;
2. Department of Pathophysiology, the Third Military Medical University, Chongqing 630038, China |
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| Abstract: | AIM:To investigate the role of K+ channels in the decreased hypoxic pulmonary vasoconstriction(HPV) in chronic hypoxic rats. METHODS:Blockers of three kinds of K+ channels, 4-AP(voltage dependent K+ channel blocker), TEA(Ca2+ activated K+ channel blocker), GLIB(ATP sensitive K+ channel blocker) were used in isolated perfused rat lungs to detect the role of K+ channels in HPV. RESULTS:In normal rats, 4-AP and TEA, but not GLIB, both elicited a significant increase in pulmonary artery baseline pressure, and also potentiated the acute hypoxic pulmonary vasoconstriction. In chronic hypoxic rats, the HPV is significantly decreased, while 4-AP, TEA, GLIB all elicited a significant but smaller increase in pulmonary artery baseline pressure. Additionally, all these three blockers potentiated the HPV stronger in chronic hypoxic rats than in control rats. CONCLUSION:The opening of Kv, KCa, KATP might modulate the hypoxic pulmonary vasoconstriction in isolated rat lungs, and the increase in this modulation by potassium channel in chronic hypoxic rats might play a role in its decrease in HPV. |
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| Keywords: | Potassium channels Anoxia Pulmonary artery |
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