Effect of Chinese recipe of replenishing kidney and activating blood circulation on senile osteoporosis of male rats

AIM: To evaluate efficiency of Chinese recipe of replenishing kidney and activating blood circulation (CRRKABC) to stave senile osteoporosis(OP) of male rats. METHODS: Forty male SD rats at age o12 months were randomly divided into 4 groups: ①24 months background control; ②27 months aging control; ③CRRKABC (low dose) and ④CRRKABC (high dose). General bone mineral density (GBMD), femur bending strength (FBS), serum-BGP and urine-Hyp/Cr were measured. RESULTS: GBMD and FBS in CRRKABC (H) group were significantly higher than those in 27 months aging control group, but lower than 24 months background control group (P<0.05); GBMD, FBS in CRRKABC groups were slightly higher than those in nylestriol's group (P>0.05). Furthermore, the level of serum-BGP in CRRKABC(H) group was higher and level of U-Hyp/Cr was lower than 27 months aging control group (P<0.05) but very close to that of 24 months background control group. The level of serum-BGP in CRRKABC (L) group was lower and level of U-Hyp/Cr was higher than 24 months background control group (P<0.05) but very close to that of 27 months background control group. CONCLUSION: CRRKABC could control osteoporosis in male rats induced by aging, in a dosedependant manner.