Regulation of‘Tiao Gan Fang Yao’on neuroendocrine-immuno-function of bandage-stressed rats |
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| Authors: | YAN Can DENG Zhong-yan WANG Jian CHEN Xiao-yin |
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| Affiliation: | 1. Department of Basic Sciences, Basic Medicine College of Guangzhou University of Traditional Chinese Medicine and Drugs, Guangzhou 510405, China;2. Department of Traditional Chinese Medical, Jinan University, Guangzhou 510632 |
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| Abstract: | AIM: To investigate the regulation of ‘Tiao Gan Fang Yao’(TGFY) on neuroendocrine-immuno-function of bandage-stressed rat . METHODS:The stressed rat model was made by bandage. RIA was adopted to measure the function of hypothalamus-pitutary-adrenal gland axis (HPAA) of stressed rat. Meanwhile, the immunity of stressed rat and the regulation of TGFY were observed.RESULTS:Bandage stress increased the contents of serum corticosterone(CORT), and ACTH, and hypothalamus corticotropin releasing hormone (P＜0.01 or 0.05), which suggested that the excitability of HPAA was enhanced. In addition, bandage stress reduced spleen lymphocyte proliferation (P＜0.01) and decreased H2O2 releasing from the macrophages significantly (P＜0.01). While TGFY could decrease HPAA excitability of bandage-stressed rat and strengthen its immunity. CONCLUSION:TGFY could regulate disorder of neuroendocrine-immuno-function of bandage-stressed rat. |
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| Keywords: | Stress Hypothalamo-hypophyseal system Immunity celular Macrophages |
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