Effect of Qing-Kai-Ling Injecta on cAMP content of hypothalamus and AVP content in ventral septal area of endotoxin-induced febrile rabbits |
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| Authors: | ZHANG Dan-hui JIANG Yu-feng HUANG Qi-fu JIA Xu YAN Jing LU Xue-ya |
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| Institution: | 1. Department of Pathology, Beijing University of Chinese Medicine, Beijing 100029, China;
2. Department of Biochemistry, Beijing University of Chinese Medicine, Beijing 100029, China |
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| Abstract: | AIM:To investigate the mechanism of Qing-Kai-Ling(QKL) Injecta suppressing endotoxin(ET)-induced fever in rabbits.METHODS:①The ET-induced fever model was established in rabbits. QKL injecta was administered intravenously, and the febrile response of rabbits was observed. The cAMP content in the hypothalamus (HP) and arginine vasopressin (AVP) content in the ventral septal area (VSA) were determined by radioimmunoassay.RESULTS:①The maximal increment in body temperature (△T) ,6 h thermal response index (TRI6)(29.59±10.39), cAMP content in the HP and AVP content in the VSA in the ET group were significantly higher than those in the normal saline (NS) group and the QKL+ET group .②The positive correlation was observed between the cAMP content in the HP and the fluctuation of body temperature (r=0.904,P＜0.01).CONCLUSION:The antipyretic mechanisms of QKL were probably due to inhibiting the increase in cAMP content in HP, and meanwhile stimulating the release of AVP in VSA. |
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| Keywords: | Endotoxins Fever Adenosine cyclic monophosphate Argipressin |
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