Detection of the IgE in cat allergic patients and analysis of the allergic reaction cause during the hyposensitization with IPC-1/IPC-2

AIM:To analyse the cause of allergic reaction during the treatment with synthetic peptide allergen IPC-1/IPC-2 (ALLERVAX CAT).METHODS:The measurement of allergen-specific IgE(as-IgE)level be fore and after the inject ion of IPC-1/IPC-2 and placebo in 27 cats allergic patients.Detection of the as-IgG,as-IgG4,as-IgE,T-IgE and histamine for one supernormal allergic person.RESULTS: No statistically significance were found in IgE in both IPC-1/IPC-2 and placebo groups. There were some obvious changes in the histamine, IgG and IgG₄ levels, and not in IgE for this supernormal patient. CONCLUSION: IPC-1/IPC-2 has no effect on the IgE. Hypernormal reaction is not related to IgE during the hyposensitization. It may be related to the IgG, especially to the IgG₄ which induce the histamine release that is non-IgE-dependent.