Effect of Xin-Tong capsule on nitric oxide production and cGMP content of ventricular myocardium in rats with experimental myocardial ischemia |
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| Authors: | YAN Qun-chao XIONG Ai-hua YANG Qin-he MO Mu-shun |
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| Institution: | 1. Medical College of Jinan University, Guangzhou 510632, China;
2. Qiaotou Hospital of Dongguan, Dongguan 511738, China |
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| Abstract: | AIM:To study the effect of xin-tong capsule on nitric oxide production and cGMP content of ventricular myocardium in rats with experimental myocardial ischemia. METHODS:Rat model of acute myocardial ischemia induced by pituitrin was used in this study, and the lift of ST segment in ECG was used as the index of myocardial ischemia. The NO2-/NO3- and cGMP contents of ventricular myocardium in rats with myocardial ischemia were determined.RESULTS: NO2-/NO3- and cGMP contents in ventricular myocardium of myocardial ischemia were (486±59) nmol/g protein and (0.38±0.08) nmol/g protein, respectively, and markedly lower than those of control (P＜0.01). After administration of Xin-Tong capsule, contents of NO2-/NO3- and cGMP in ventricular myocardium of rats with myocardial ischemia were obviously elevated . In comparison with control, ST segment of ECG in rats with myocardial ischemia was lifted, and the lift peak of ST segment occur in 45 min after myocardial ischemia (P＜0.01). Pretreatment of Xin-Tong capsule can improve conditions of myocardial ischemia . CONCLUSION:Xin-Tong capsule can elevate the contents of nitric oxide and cGMP, and attenuate myocardial ischemia injury in rats. |
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| Keywords: | Drugs Chinese herbal Myocardium Ischemia Nitric oxide Guanosine cyclic monophosphate |
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