Effect of lansoprazole on gastric ulceration in rats |
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| Authors: | XU Hua YU Li-ping WEN Jie ZHAO Wen HUANG Ya-dong LI Xiao-kun |
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| Affiliation: | 1. Biopharmaceutical R&D Center of Jinan University, Guangzhou 510632, China;2. Drug R&D Center of Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China |
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| Abstract: | AIM:To investigate the effect of lansoprazole on gastric ulceration in rats. METHODS:Using the gastric ulcer model induced by hemorrhagic shock, restraint water-immersion stress and pylorus-ligature, the protective effect of lansoprazole (iv) on gastric ulceration was observed. RESULTS:Pretreatment with lansoprazole (7.5-60 mg/kg) significantly inhibited the formation of gastric ulcer in the three models in a dose-dependent manner. The autiulcer efficacy of lansoprazole was similar to that of omeprazole in the equal dose, but stronger than that of omeprazole for ulcer induced by water-immersion stress.CONCLUSION:The intravenously administered lansoprazole inhibited formation of experimental gastric ulcer in rats. |
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| Keywords: | Lansoprazole Shock hemorrhagic Stomach ulcer Stress Rats |
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