Pathogenesis of early cardiac myocyte damage after severe crush injury |
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| Authors: | LIU Shui-ping CHEN Yu-chuan LIU Xiu-qin GUO Wei CHENG Jian-ding |
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| Institution: | 1. Department of Forensic Pathology, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China;
2. Department of Nuclear Medicine, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China |
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| Abstract: | AIM:To study the changes of plasma atrial natriuretic peptide(ANP), endothelin-1 (ET-1) and serum cardiac troponin I(cTnI) levels and the effects of ANP and ET-1 on myocardium in crush injury rats.METHODS:Crush injury was produced in SD rats,the serum levels of cardiac enzyme and cardiac troponin I,plasma levels of ANP and ET-1 were studied by automated biochemical analyzer,automated chemiluminescence assay and radioimmunoassay. RESULTS:The plasma ET-1 level was much lower,the levels of plasma ANP and serum cardiac enzyme and cTnI were much higher after crush injury than those of the control group(P＜0.05).CONCLUSION:ANP and ET-1 may play an important role in cardiomyocyte injury in the early stage of crush injury. |
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| Keywords: | Crush syndrome Endothelin-1 Atrial natriuretic factor Troponin |
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