Effect of glucagon-like peptide-1(7-36)NH2 on insulin secretion and membrane potentials of pancreatic islet β-cells |
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Authors: | WANG Yi-fei WANG Jie-yi WANG Guo-hua |
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Affiliation: | 1. Department of Endocrinology, Guangzhou General Hospital of PLA, Guangzhou 510010, China;2. Department of Endocrinology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China |
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Abstract: | AIM: To observe pathomorphological changes in cerebral cortex and hippocampus in the mouse with synthetic vascular dementia. METHODS: The synthetic vascular dementia model was produced in the mouse. Animals were killed 7 d, 15 d, and 30 d after the operation, brain tissues were removed and embedded in paraffin. Section of 8μm thickness were stained with hematoxylin-eosin(HE) and Nissl methods, and observed with light microscope. RESULTS: The cerebral cortex in the mouse became thinner on the seventh day, karyopyknosis in partial nervous cells was formed, the number of local neurons was reduced, sieve structure was observed, and glial cells proliferated, with the similar results 15 d and 30 d after operation. Model mouses hippocampal cells in CA1 area were reduced and almost disappeared 30 d after operation. At the same time, glial cells were abundantly proliferated, tubercles were formed. Cells in CA2, CA3 area were also reduced and hippocampal sclerosis occurred. CONCLUSION: Delayed necrosis of hippocampal pyramidal cells may be the pathological basis of ischemia cerebral vascular dementia. |
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Keywords: | Glucagon Rats Islets of langerhans Insulin Membrane potential |
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