The mechanism of intercellular adhesion molecule-1 expression in endothelial cells stimulated by advanced glycosylation end products |
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| Authors: | YU Lu QIU Hong-xin WANG Ya-ping SI Liang-yi WU Shan ZHU Ji-hua |
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| Institution: | 1. Department of Endocrinology, College of Clinical Medicine, Chongqing University of Medical Sciences, Chongqing 400015, China;
2. Department of Endocinology, Beijing Tongren Hospital, Beijing 100005, China |
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| Abstract: | AIM: To explore the relationship between intercellular adhesion molecule-1(ICAM-1)expression in endothelial cells(EC) and advanced glycosylation end products(AGEs) stimulation. METHODS: Murine bone marrow derived ECs was stimulated by AGEs after pretreated with anti-AGEs, anti-IL-1β and N-acetylcysteine(NAC),then SOD activity and ICAM-1 concentration and adhesion rate(AR) were evaluated. RESULTS: ECs which expressed ICAM-1 induced by AGEs showed lower SOD activity . The ICAM-1 expression as well as the increase of AR caused by AGEs stimulation could be suppressed by anti-AGEs(0.12±0.01) and NAC(0.11±0.05). Anti-IL-1β had no influence on these changes. CONCLUSION: AGEs could induce endothelial cells to express ICAM-1 in vitro, most probably due to the formation of free radicals. Besides, AGEs may stimulate other cells to secrete cytokines resulting in ICAM-1 expression in endothelial cells. |
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| Keywords: | Glycosylation end products advanced Cell adhesion molecule Endothelium Cells Free radicals |
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