Influence of Nao-xue-bao on blood coagulation and platelet aggregation in rats |
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Authors: | HUA Kun LI Tian-shu GAO Ling ZHU Shi-gong |
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Affiliation: | Department of Pathophysiology, Norman Bethune University of Medical Sciences, Changchun 130021, China |
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Abstract: | AIM and METHODS:To study the effect of Nao-xue-bao at three different doses on blood coagulation,platelet aggregation by observing the changes in activated partial thromboplastin time (APTT), prothrombin time (PT), antithrombin-Ⅲ(AT-III), fibrinogen(Fng), plasminogen(Plg) and platelet aggregation(PAG). RESULTS:Compared with thrombosis group, the rats treated with Naoxuebao showed that the plasma APTT,PT were longer, and the activity of AT-III was increased. The content of Fng was reduced, TT was longer, there was a negative correlation between Fng and TT. Furthermore PAG-1, PAG-5 and PAG-M were reduced. CONCLUSION: Nao-xue-bao could inhibit thrombosis in different keys of blood coagulation. |
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Keywords: | Thrombosis Blood platelets Drugs Chinese herbal |
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