Effects of calmodulin antagonist and slow calcium channel antagonist on reperfusion injury of isolated rat hearts in calcium paradox |
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Authors: | SONG Dong-zhe YAO Lu CHEN Zhi-zhou YUE Yuan-kun SUN Hai-yan LIU Cheng-yu TAN Run-luan LU Xin-yi LIU Li-qiu |
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Institution: | 1. Department of Cardiology, The Affiliated Hospital of Qingdao Medical College, Qingdao University, Qingdao 266003, China;
2. Department of Diagnostics, Qingdao Medical College, Qingdao University, Qingdao 266021, China;
3. The 401 th Qingdao Naval Hospital, Qingdao 266071, China |
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Abstract: | AIM: To observe the protective effect of calmodulin antagonist trifluoperazine(TFP) and slow calcium channel antagonist verapamil (VP) upon calcium overload injury. METHODS: The calcium content of the myocardium, lactate dehydrogenase (LDH) release, protein loss and coronary flow were measured after the isolated rat hearts were perfused by TFP and VP. RESULTS: TFP could significantly reduce the tissue calcium , LDH release and protein loss of the myocardium ( P <0.01) while VP had no such effects.The above indexes were further reduced when TFP and VP were used simutaneously( P <0.01).CONCLUSION:TFP can effectively alleviate the severity of the myocardium injury during calcium paradox while VP has no such effects.The simultanous use of VP and TFP is more effective in preventing tissue damage of the heart than the use of TFP alone.The massive influx of Ca2+ in calcium paradox is mainly a calmodulin related process. |
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Keywords: | Trifluoperazine Verapamil Myocardial reperfusion injury Calcium channels |
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