An experimental exploration of focal inflammatory response in cerebral ischemic foci in the rat |
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Authors: | LEI Wan-long LIU Yong YUANG Qun-fang YAO Zhi-bin LING Feng-dong |
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Institution: | 1. Department of Anatomy, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China;
2. Department of Anatomy, Xi’an Medical University , Xi’an, 710061, China |
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Abstract: | AIM: To study the pathological relationship of vascular cell adhesion molecule-1 (VCAM-1) expression and monocyte/macrophage infiltration with focal brain ischemia. METHODS: Immunohistochemical technique and focal brain ischemia/reperfusion model were used in the study in order to explore profiles and time-course of VCAM-1 expression and monocyte macrophage (ED2 positive cell) infiltration in ischemic rat brain. RESULTS: VCAM-1 was up-regulated in microvascular endothelial cells in ischemic cortex at 1h postischemia, and continuously expressed during the time of reperfusion. ED2 positive cells infiltrated into ischemic cortex at 1h iscehmia/ 2h reperfusion and then ED2 positive cells increased gradually with the time of reperfusion, ED2 positive cell infiltration showed apparently relationship with VCAM-1 expression, and both of them exhibited the some changes of time-dependence. CONCLUSION: Cerebral ischemia induced VCAM-1 expression and ED2 positive cell infiltration and VCAM-1 may regulate the recruitment of ED2 positive cells in the ischemic brain region. The results suggested that VCAM-1 and ED2 positive cells may be participated in the pathogenesis of cerebral ischemic injury. |
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Keywords: | Endothelium vascular Macrophages Brain Ischemia Reperfusion |
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