The reversal effects of recombinant human augmenter of liver regeneration in immunocomplex induced liver fibrosis |
| |
Authors: | WANG Ai-min DU Shuang-cun YANG Xiao-ming GUO Rui-feng WANG Qing-ming HE Fu-chu |
| |
Affiliation: | 1. 252 Hospital of PLA, Baoding 071000, China;2. Academy of Militory Medical Science, Beijing 100850, China |
| |
Abstract: | AIM: To observe the anti-fibrosis activity of recombinant human augmenter of liver regeneration (hALR). METHODS: Albumin induced rat model of liver fibrosis was established and hALR was given peritoneally after the model production. Serum concentration of alanine aminotransferase(ALT),aspartic aminotransferase(AST),lactate dehydrogenase(LDH), hepatic collagen contents and pathological examination were selected as observing parameter. RESULTS: Recombinant human augmenter of liver regeneration (hALR) could decrease ALT, AST, LDH concentration of fibrotic rats. The measurements of hepatic collagen contents showed that hepatic collagen contents in hALR treatment group was much lower than those of model group and negative control group. Pathological examination also indicated that the degree of liver fibrosis in hALR treatment group was attenuated in comparison with those of model group and negative control group. CONCLUSION: Recombinant human augmenter of liver regeneration (hALR) had reversal effects on immunocomplex induced rat liver fibrosis.control group. CONCLUSION: Recombinant human augmenter of liver regeneration (hALR) had reversal effects on immunocomplex induced rat liver fibrosis. |
| |
Keywords: | Recombinant proteins Immunostimulating complexes Liver diseases |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
|
点击此处可从《园艺学报》下载全文 |
|