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Protective effect of bactericidal/permeability-increasing protein on sepsis induced by intra-abdominal infection in rats
Authors:JIANG Jian-xin  XIE Guo-qi  LIU Da-wei  ZHU Pei-fang  WANG Zheng-guo  HE Ya-ni  ZHOU Ji-hong  XU Hong
Affiliation:Research Institute of Surgery, Daping Hospital, the Third Military Medical University, Chongqing 400042, China
Abstract:AIM:To investigate the protective effect of bactericidal/permeability-increasing protein (BPI) on sepsis induced by intra-abdominal infection in rats and its mechanism.METHODS:Intra-abdominal infection induced sepsis was reproduced by cecal ligation and puncture (CLP). BPI or equal volume of physiological saline was intra-abdominally given immediately after CLP and 12 hours after CLP respectively (2.5 mg/kg of BPI each time). Plasma endotoxin levels were determined with limulus amebocyte chromogenic assay.RESULTS:(1)The survival time in BPI group was significantly higher than in physiological saline (PS) group. (2)The values of MAP, LVSP, IP, d p /d t max and-d p /d t max in BPI group, although decreasing,were markedly higher than those in PS group. (3) Plasma glutamate-pyruvate transaminase and urea nitrogen levels in BPI group, though increasing, were significantly lower than those in PS group.(4) There was no significant change of plasma endotoxin levels in BPI group, while plasma endotoxin levels were markedly increased in PS group. There was significantly different between two groups. CONCLUSIONS:BPI has an obvious protective effect on intra-abdominal infection induced sepsis, which might be related to its antagonism against endotoxin.
Keywords:Abdomen  Infection  Bacterial proteins  Rats  
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