Effect of bFGF on human kidney fibroblasts |
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| Authors: | WEI Ying FAN Jun-ming PAN Li-ping OUYANG Xiao-sen |
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| Institution: | 1. The Red Cross Hospital of Yunnan, Kunming 650021, China;
2. Division of Nephrology, Department of Internal Medicine, the First Affiliated Hospital, West China University of Medical |
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| Abstract: | AIM: To study the effect of bFGF on cell proliferation, secretion of type I collagen and expression of integrin β1 in human kidney fibroblasts(KFB). METHODS: The KFB was cultured and stimulated by bFGF in vitro. The proliferation and collagen I secreting of KFB, the expression of integrin β1 were measured by MTT, ELISA and flow cytometer, respectively. RESULTS: bFGF(25-50 μg/L) could obviously stimulate the cell proliferation(P< 0.05), promote the secretion of collagen I(P< 0.05) and enhance the expression of integrin β1(P< 0.05) in human kidney fibroblast. CONCLUSION: bFGF could induce renal interstitial fibrosis by promoting cell proliferation, secretion of collagen I and integrin β1 expression of KFB. |
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| Keywords: | Fibroblast growth factor basic Kidney Fibroblasts Integrins |
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