Alteration of serum interleukin-6 and tumor necrosis factor-α after ischemic stimulation of coronary artery in PTCA |
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Authors: | LI Fang KONG Xian-ming WANG Guang-gong CHEN Ji-lin LI Ji-fu CHEN Yu-guo LI Gui-shuang LIU Tong-tao PAN Qi-xing |
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Institution: | 1. Department of Heart Medicine, the Affiliated Hospital of Shandong Medical University, Jinan 250012, China;
2. Department of Cardiology, Fuwai Hospital, CAMS, Beijing 100037, China |
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Abstract: | AIM: Inflammatory responses play an important role in the post- percutaneous transluminal coronary angioplasty (PTCA) restenosis and has been demonstrated occuring immediately after PTCA. Interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) are the main inflammatory cytokines. We try to compare the changes in interleukin-6(IL-6) and TNF-α after PTCA in the patients with and without collateral circulation to probe into the pathogenesis of early inflammatory response. METHODS: The extent of myocardial ischemia induced by balloon inflation was quantified by a scoring system referring to the Leaman coronary score. The IL-6、TNF-α levels of coronary heart disease group and control group before and after PTCA are calculated. RESULTS: The concentrations of IL-6 and TNF-α were (9.592±1.847) ng/L and (26.959±1.967) ng/L, respectively, and were significantly increased 4 hours after PTCA. CONCLUSION: IL-6 and TNF-α are sensitive indicators of the early inflammatory response after PTCA. Ischemia scores reflected the extent of ischemia reperfusion injury during PTCA. Collateral circulation decreased the early inflammatory response after PTCA. |
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Keywords: | Myocardial ischemia Reperfusion Interleukin-6 Tumor necrosis factor |
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