Alteration of local renin-angiotensin system of dogs with myocardial ischemia and external counterpulsation treatment |
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| Authors: | LU Li WU Wei-kang ZHENG Zhen-sheng QIAN Xiao-xian |
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| Affiliation: | 1. Department of pathophysiology, Guangzhou Medical College, Guangzhou 510182, China;2. Department of pathophysiology, Sun Yet-sen University of Medical Sciences, Guangzhou 510089, China;3. Key Laboratory on Assisted Circulation Ministry of Health, Sun Yet-sen University of Medical Sciences, Guangzhou 510089, China |
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| Abstract: | AIM:To examine the alteration of local renin-angiotensin system of dogs with myocardial ischemia and external counterpulsation treatment and its mechanism. METHODS:Acute myocardial ischemia was induced by occluding the LAD of ischemic and ECP groups. The tissue renin activity and angiotensin(AngⅡ) level in ischemic myocardium and aorta were measured. The expression of angiotensinogen and renin mRNA were detected by RT-PCR. RESULTS:Renin activity, AngⅡ level in ischemic myocardium and AngⅡ level in aorta of ECP group were lower than those of MI group. Except for renin in ischemic myocardium, angiotensinogen mRNA and renin in ischemic myocardium and angiotensinogen mRNA in aorta of ECP group were reduced to normal level. CONCLUSION:The inhibitory effect of ECP on cardiovascular renin activity and angiotensinogen gene expression could be one of the mechanisms by which ECP protects ischemic myocardium. |
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| Keywords: | Myocardial ischemia Renin-angiotensin system Counterpulsation |
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