Effect of ligustrazine on pulmonary arterial pressure and pulmonary arterial wall collagen of chronic hypoxic hypercapnic rats |
| |
Authors: | GAO Zhi-jie WANG Liang-xing WANG Qun-ji XIE Yu-peng CHEN Yan-fan CHEN Shao-xian WANG Wei |
| |
Institution: | Institute of Cor Pulmonale, Wenzhou Medical College, Wenzhou 325000, China |
| |
Abstract: | AIM:To study the effect of ligustrazine on pulmonary hypertensive rats induced by hypoxic hypercapnia. METHODS:Thirty rats were randomly divided into three groups:control group(A),hypoxic hypercapnic group(B), hypoxic hypercapnia+ligustrazine(lig.) group(C). RESULTS: (1) Mean pulmonary arterial pressure(mPAP)of group B was significantly higher than that of group A and mPAP of group C was significantly lower than that of group B(P<0.01),differences of mean carotid pressure(mCAP) were not significant among three groups (P>0.05); (2)Electron microscopy and immunohistochemistry showed ligustrazine could inhibit the diposition of collagenous fiber(collagen typeⅠ)in pulmonary arterioles induced by hypoxic hypercapnia; (3) Plasma endothelin level of group C was significantly lower than that of group B (P<0.01), serum (NO 2-/NO3-) of group C was significantly higher than that of group B (P<0.01). CONCLUSION:Ligustrazine can inhibit pulmonary hypertension and the diposition of collagen type Ⅰ in pulmonary arterial wall induced by hypoxic hypercapnia. |
| |
Keywords: | Drugs Chinese herbal Anoxia Hypercapnia Hypertension pulmonary Collagen |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|