The alteration of urotensin-II receptors in rat aorta after balloon angioplasty injury |
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| Authors: | XIA Chun-fang XU Shao-ping ZHANG Yong-gang YANG Jun HUO Yong PANG Yong-zheng TANG Chao-shu |
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| Institution: | 1. Institute of Cardiovascular Research, the First Hospital, Peking University, Beijing 100034, China;
2. Cardiovascular Department, General Hospital of Beijing Military Command, Beijing 100700, China |
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| Abstract: | AIM:To observe the alteration of urotensin II (UII) receptors and contractile response to UII in rat aorta after balloon angioplasty injury. METHODS: The plasma membrane isolated from balloon injured aorta was used to study the binding of 125-UII to the membrane and the contractile potency of UII on rat aorta was assayed. RESULTS: In contrast to the normal aorta, the contractile potency to UII enhanced in balloon injury artery and the calculated maximal number of specific binding sites (Bmax) was increased about 44% and 36% respectively in rat artery after balloon injury 3 and 21 days (P＜0.01). CONCLUSION: The density of UII receptors and the contractile response to UII had changed after balloon angioplasty injury. It was proposed that UII might play an important role in the intervention of restenosis after angioplasty. |
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| Keywords: | Urotensins Receptor endogenous substances Angioplasty balloon Rats Aorta |
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