Effects of repeated hypoxia on the NPY-like immunoreactivity in the mouse brain |
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Authors: | HOU Yan-zhi JIAO Xiao-hui LU Guo-wei GAO Cui-ying |
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Institution: | 1. Department of Biochemistry ,Cpaital University of Medical Sciences, Beijing 100054, China;
2. Department of Neurobiology, Cpaital University of Medical Sciences, Beijing 100054, China |
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Abstract: | AIM:To observe the effects of repeated hypoxia on the neuropeptide Y(NPY)-like immunoreactivity in the mouse brain. METHODS:Forty male kunming mice were divided into 5 groups: Control, H1(after the 1sthypoxic run), H2(the 2nd hypoxic run), H3(the 3rdhypoxic run)and H4(the 4th hypoxic run). The hypoxic groups were subjected to different runs of hypoxia exposure. The NPY-like immunoreactivity in the moue brain was measured by using radioimmunoassary method.RESULTS: The standard tolerance time of the mouse exposed to hypoxia significantly increased following each increase in runs of hypoxia exposure. After the 1st and 2nd hypoxic run the NPY-like immunoreactivities in the mice brain significantly increased by 145.5%±3.2% and 147.3%±2.5% compared with the control(P<0.01), respectively. However, the NPY-like immunoreactivites returned to the control levels after the 3rd run. CONCLUSION:The repeated exposure to hypoxia can significantly enhance mouse's tolerance to hypoxia by preconditioning, and can induce the increase by only one exposure in NPY-like immunoreactivities of the mouse brain during the early period of formation of hypoxic preconditioning. |
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Keywords: | Neuropeptide Y Anoxia Adaptation physiological |
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