The relaxation of rabbit femoral artery induced by cAMP is partly dependent on nitric oxide |
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| Authors: | GAO Ling XU Biao Albert FERRO |
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| Institution: | 1. The Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, China;
2. St. Thomas Hospital, King' College, England |
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| Abstract: | AIM:To determine whether vasorelaxation induced by cAMP is dependent on eNOS activation.METHODS:A constant perfusion model of rabbit femoral artery was used to observe the changes of perfusion pressure before and after intra-arterial infusing different concentrations of dbcAMP(a membrane-permeable cAMP analogue) or forskolin(a direct stimulator of adenyl cyclase) and the effects of NOS inhibitor L-NAME on their actions.RESULTS:Both dbcAMP and forskolin induced concentration-dependent relaxation of rabbit femoral artery bed and NOS inhibitor L-NAME partly inhibited this vasorelaxation.CONCLUSION:Vasorelaxation induced by cAMP is mediated partly through eNOS activation. |
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| Keywords: | Adenosine cyclic monophosphate Nitric oxide Femoral artery Endothelium |
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