Inhibitory effects of dexamethasone on the expression of integrin CD18 induced by PMA |
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| Authors: | HE Xiao-wen LIU Yu-jian LI Jun PAN Zhen ZHONG Ji-gen LU Jian |
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| Institution: | 1. Naval Medical Research Institute, the Second Military University, Shanghai 200433, China;
2. Department of pathophysiology, the Second Military University, the Second Military University, Shanghai 200433, China;
3. Department of Naval medicine, the Second Military University, Shanghai 200433, China |
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| Abstract: | AIM:To study the effect of dexamethasone(Dex) on the expression of CD18. METHODS:Quantitative RT-PCR analysis, Northern blotting technique were used to measure the expression of CD18 in U937 cells treated by PMA.RESULTS:Dex could significantly attenuated the effects of PMA in a dose-dependent manner (10-6 mol/L-10-10 mol/L). These effects of Dex (10-7 mol/L) were completely aborted by RU-486 (10-6 mol/L).CONCLUSION:Dex, via GR, could inhibit CD18 mRNA expression in U937 cells treated by PMA. The effects of Dex might be possibly depended on the counteracting action on the NF-κB. |
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| Keywords: | Dexamethasone Phorbol esters NF-kappa Β RNA messenger |
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