Comparative studies on dialyzable leukocyte extracts containing transfer factor—A review |
| |
| Authors: | Phillip H Klesius H.Hugh Fudenberg Charles L Smith |
| |
| Affiliation: | 1. Regional Parasite Research Laboratory, U.S. Department of Agriculture, Science and Education Administration, Agriculture Research, Auburn, AL 36830 and Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, Charleston, SC 29403, U.S.A. |
| |
| Abstract: | The current state of knowledge concerning dialyzable leukocyte extracts (DLE) containing transfer factor (TF) is reviewed. Recent studies indicate that antigen-specific TF is an RNA-peptide component(s) of DLE that promotes antigen-specific cell-mediated reactivity (CMR). DLE also has nonspecific (adjuvant) activities both in vivo and in vitro. The term TF is now restricted to antigen-specific activity related to the promotion of dermal delayed-type hypersensitivity reactions and production of mediators of cellular immunity (lymphokines). Comparative studies of DLE containing TF activity in humans, non-human primates, and non-primates (cows) are discussed. Other animal models, including guinea pigs, dogs, mice, rats, and rabbits, are reviewed. |
| |
| Keywords: | Dialyzable leukocyte extract transfer factor delayed-type hypersensitivity lymphokine production antigen-specific and nonspecific effects on cell-mediated immunity cell-mediated reactivity animal transfer factor models comparative transfer factor studies Extraits dialysables leucocytaires facteur de transfert hypersensibilité retardée production de lymphokine effet antigénique spécifique et non spécifique sur l'immunité à médiation cellulaire modèle animal pour le facteur de transfert études comparatives du facteur de transfer |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
