| 茶多酚及儿茶素对前列腺癌细胞生长的抑制作用 |
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| 引用本文： | 张星海,杨贤强.茶多酚及儿茶素对前列腺癌细胞生长的抑制作用[J].茶叶,2003,29(3):142-144,158. |
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| 作者姓名： | 张星海 杨贤强 |
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| 作者单位： | 浙江大学茶学系,杭州,310029 |
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| 摘 要： | 前列腺癌是最常见的恶性肿瘤之一。茶多酚及其儿茶素单体对前列腺癌细胞具有明显的抑制和诱导凋亡作用 ,作用效果的 IC50 顺序为 88、97、112μM(EGCG>ECG>EGC) ,EC几乎没有作用 ,但含 EC的 TPS(茶多酚 )和不含 EC的 TPS存在差异 ,它们的 IC50 为 39μg/ m l和 4 3μg/ m l,且成剂量效应和时间效应关系。同时用荧光显微镜可以看到癌细胞的凋亡小体。
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| 关 键 词： | 茶多酚 儿茶素 前列腺癌 细胞生长 抑制作用 恶性肿瘤 作用效果 凋亡小体 |
| 文章编号： | 0577-8921(2003)03-142-03 |
Study on the effect of prostate cancer cell by Tea Polyphenols |
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| Zhang xing hai,yang xian qiang.Study on the effect of prostate cancer cell by Tea Polyphenols[J].Journal of Tea,2003,29(3):142-144,158. |
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| Authors: | Zhang xing hai yang xian qiang |
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| Abstract: | Prostate cancer is one of the most common cancers. Green tea components exert many biological effects, including antitumor and cancer preventive activities. In the search for anticancer agents foe prostate cancer, the inhibitory effects of green tea components were tested on the prostate cancer cell line PC 3, EGCG, ECG, EGC, TPs, TPS+EC except EC proved to have potent at inhibiting cell growth, especially EGCG, showed effect dose and time relationship, lhe inhibition induced be EGCG was found to occur via apoptotic cell death as shown by changes in nuclear morphology and DNA fragmentation. |
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| Keywords: | Tea Polyphenols tea catechins prostate cancer apotosis |
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