Demonstration of both immunologically unique and common antigenic determinants in Dirofilaria immitis and Toxocara canis using monoclonal antibodies

Using an ELISA system, the immunological cross-reactivity between D. immitis and T. canis has been, for the first time, examined on an individual clone-by-clone basis. This study offers a definitive demonstration of the presence of immunologically distinguishable species-specific non-crossreactive antigens and the presence of cross-reactive antigens in antigenic extracts obtained from adult D. immitis and T. canis.