Cutaneous presentation of canine intravascular lymphoma (malignant angioendotheliomatosis) |
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Authors: | YA vanGessel SP McDonough HJ McCormick & BA Summers |
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Institution: | Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA;Saranac Veterinary Clinic, 3900 Route 3, PO Box 67, Saranac, NY 12981, USA |
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Abstract: | A 9-year-old female spayed Boxer dog presented with variably sized, firm, black, raised, exudative subcutaneous masses on her head, neck and trunk, that tended to fluctuate in size and frequently ulcerate. Skin biopsy showed that the dermis was expanded by a densely cellular mass of proliferative capillaries distended with large pleomorphic neoplastic round cells mixed with fibrin and erythrocytes. Intravascular lymphoma was diagnosed and immunostains were compatible with a CD8+ T lymphocyte histogenesis (CD3+/CD79a?/TCRαβ+/CD8α+). Post-mortem examination, four months after diagnosis, revealed neoplastic T-cells within meningeal arteries. We are unaware of other reports of a cutaneous presentation and ante-mortem diagnosis of intravascular lymphoma in the dog. Additionally, this vasoproliferative form of intravascular lymphoma has not been previously described in dogs. |
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Keywords: | CD3 complex dog intravascular lymphoma immunohistology malignant angioendotheliomatosis skin disease |
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