Infectious prions in the saliva and blood of deer with chronic wasting disease |
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| Authors: | Mathiason Candace K Powers Jenny G Dahmes Sallie J Osborn David A Miller Karl V Warren Robert J Mason Gary L Hays Sheila A Hayes-Klug Jeanette Seelig Davis M Wild Margaret A Wolfe Lisa L Spraker Terry R Miller Michael W Sigurdson Christina J Telling Glenn C Hoover Edward A |
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| Institution: | Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biological Sciences (CVMBS), Colorado State University (CSU), Fort Collins, CO 80523, USA. |
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| Abstract: | A critical concern in the transmission of prion diseases, including chronic wasting disease (CWD) of cervids, is the potential presence of prions in body fluids. To address this issue directly, we exposed cohorts of CWD-na?ve deer to saliva, blood, or urine and feces from CWD-positive deer. We found infectious prions capable of transmitting CWD in saliva (by the oral route) and in blood (by transfusion). The results help to explain the facile transmission of CWD among cervids and prompt caution concerning contact with body fluids in prion infections. |
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