| Inhibition of Na＋,K＋-ATPase in Housefly （Musca domestica L.） by Terpinen- 4-ol and Its Ester Derivatives |
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| 作者姓名： | GUO Zhi-bo MA Zhi-qing FENG Jun-tao ZHANG Xing |
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| 作者单位： | [1]Research ＆ Development Center of Biorational Pesticide, Northwest A＆F University/Technology and Engineering Center of Biopesticide, Shaanxi Province, Yangling 712100, P.R. China [2]College of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, P.R.China |
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| 基金项目： | This research was financially supported by the National Natural Science Foundation of China （30600404）. |
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| 摘 要： | To reveal the insecticidal mechanism of terpinen-4-ol, the activity of Na＋,K＋-ATPase in insects tested were determined in vivo and in vitro. The results showed that terpinen-4-ol and its ester derivatives had strong contact activity to housefly and the contact toxicities of its derivatives except Z3 were all superior or equivalent to terpinen-4-ol. All the 7 compounds had strong inhibition towards activity of Na＋,K＋-ATPase. With poisoning symptom exacerbating, the inhibition rates were gradually increased. In vitro, the IC50 of terpinen-4-ol, Z1, Z2, Z4, Z5, and Z6 was 155.89, 197.98, 96.02, 121.36, 124.85, and 153.74 μg mL% respectively. There was well correlation between the LDs0 of terpinen-4-ol derivatives to housefly and the IC50 of terpinen-4-ol derivatives to Na＋,K＋-ATPase in housefly. In conclusion, Na＋,K＋-ATPase was likely the target of terpinen-4-ol against insects.
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| 关 键 词： | 酯类衍生物 ATP酶 松油烯 醇酯 家蝇 钠 钾 IC50 |
Inhibition of Na+,K+-ATPase in Housefly(Musca domestica L.)by Terpinen-4-ol and Its Ester Derivatives |
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| GUO Zhi-bo,MA Zhi-qing,FENG Jun-tao,ZHANG Xing.Inhibition of Na+,K+-ATPase in Housefly(Musca domestica L.)by Terpinen-4-ol and Its Ester Derivatives[J].Agricultural Sciences in China,2009,8(12):1492-1497. |
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| Authors: | GUO Zhi-bo MA Zhi-qing FENG Jun-tao ZHANG King |
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| Institution: | 1. Key Laboratory of Integrated Pest Management in Crops in Eastern China (Ministry of Agriculture of China), College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China;2. Institute of Plant Protection, Hunan Academy of Agricultural Sciences, Changsha 410125, China;3. Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China |
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| Abstract: | To reveal the insecticidal mechanism of terpinen-4-ol, the activity of Na+,K+-ATPase in insects tested were determined in vivo and in vitro. The results showed that terpinen-4-ol and its ester derivatives had strong contact activity to housefly and the contact toxicities of its derivatives except Z3 were all superior or equivalent to terpinen-4-ol. All the 7 compounds had strong inhibition towards activity of Na+,K+-ATPase. With poisoning symptom exacerbating, the inhibition rates were gradually increased. In vitro, the IC50 of terpinen-4-ol, Z1, Z2, Z4, Z5, and Z6 was 155.89, 197.98, 96.02, 121.36, 124.85, and 153.74 μg mL?1, respectively. There was well correlation between the LD50 of terpinen-4-ol derivatives to housefly and the IC50 of terpinen-4-ol derivatives to Na+,K+-ATPase in housefly. In conclusion, Na+,K+-ATPase was likely the target of terpinen-4-ol against insects. |
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| Keywords: | terpinen-4-ol terpinen-4-ol ester derivatives Na+ K+-ATPase Musca domestica L |
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