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Gamma-aminobutyric acid antagonism and presynaptic inhibition in the frog spinal cord |
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| Authors: | R A Davidoff |
| Abstract: | The convulsant alkaloid bicuculline blocked presynaptic inhibition, dorsal root potentials, primary afferent depolarization, and depolarizing effects of gamma-aminobutyric acid on dorsal root terminals of the amphibian spinal cord, but did not block effects of other putative amino acid transmitters. These actions of bicuculline suggest that gamma-aminobutyric acid may be the transmitter involved in spinal presynaptic inhibition. |
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