Use of the caprinised strain of rinderpest virus for potency testing an attenuated cell culture rinderpest vaccine |
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Authors: | F. Guillemin P. Jouvenet M. Mosienyane M. Mannathoko |
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Affiliation: | Botswana Vaccine Institute, Gaborone. |
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Abstract: | The caprinised strain of rinderpest virus was inoculated into goats to produce a challenge stock. These goats were kept with control animals (goats, sheep, calves). In this trial the caprinised strain was shown to have a mild pathogenicity for goats and it spread to one of two contact goats but not from goats to other species. The caprinised strain was then tested on cattle where a febrile reaction was observed. The caprinised strain also did not spread between cattle. The cattle vaccinated with a freeze-dried vaccine produced from the attenuated Kabete RBKO strain on bovine kidney cells were then challenged with the caprinised strain with good results. |
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