Use of the caprinised strain of rinderpest virus for potency testing an attenuated cell culture rinderpest vaccine |
| |
Authors: | F Guillemin P Jouvenet M Mosienyane M Mannathoko |
| |
Institution: | Botswana Vaccine Institute, Gaborone. |
| |
Abstract: | The caprinised strain of rinderpest virus was inoculated into goats to produce a challenge stock. These goats were kept with control animals (goats, sheep, calves). In this trial the caprinised strain was shown to have a mild pathogenicity for goats and it spread to one of two contact goats but not from goats to other species. The caprinised strain was then tested on cattle where a febrile reaction was observed. The caprinised strain also did not spread between cattle. The cattle vaccinated with a freeze-dried vaccine produced from the attenuated Kabete RBKO strain on bovine kidney cells were then challenged with the caprinised strain with good results. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |