Role of neuropeptide Y (NPY) in the regulation of reproduction: study based on catfish model |
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Authors: | Nishikant Subhedar Archana Gaikwad K C Biju Subhash Saha |
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Institution: | (1) Department of Pharmaceutical Sciences, Nagpur University Campus, Nagpur, 440 033, India |
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Abstract: | Significance of NPY in the regulation of GnRH–LH axis was evaluated. Considerable NPY immunoreactivity was seen in the components
like olfactory system, basal telencephalon, preoptic and tuberal areas, and the pituitary gland that serve as neuroanatomical
substrates for processing reproductive information. Close anatomical association as well as colocalizations of NPY and GnRH
were seen in the olfactory receptor neurons, olfactory nerve fibers and their terminals in the glomeruli, ganglion cells of
nervus terminalis, medial olfactory tracts, fibers in the ventral telencephalon and pituitary. In the pituitary, NPY fibers
seem to innervate the GnRH as well as LH cells. Intracranial administration of NPY resulted in significant increase in the
GnRH immunoreactivity in all the components of the olfactory system. In the pituitary, NPY augmented the population of GnRH
fibers and LH cells. HPLC analysis showed that salmon GnRH content in the olfactory organ, bulb, preoptic area+telencephalon
and pituitary was also significantly increased following NPY treatment. NPY may play a role in positive regulation of GnRH
throughout the neuraxis and also up-regulate the LH cells in the pituitary. |
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Keywords: | Immunocytochemistry Peptides Olfactory system Forebrain GnRH– LH axis Teleosts |
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