Effect of Solcoseryl® on the clinical course of experimental Escherichia coli-endotoxin mastitis

Experimental Escherichia coli -endotoxin mastitis was induced in a single quarter in twenty-eight cows. The inflamed quarters of six of the cows were treated with 50 mg Solcoseryl® infusion in an oil base starting 4–6 h after endotoxin infusion, and four additional infusions were given at 12-h intervals. The inflamed quarters of eight of the cows were similarly treated with 200 mg Solcoseryl® whereas the remaining fourteen cows served as control. Solcoseryl® treatment did not alter the systemic or local course of acute mastitis. Local reaction, as assessed by the California Mastitis Test (CMT), however, subsided considerably sooner in quarters treated with Solcoseryl®, and the effect of Solcoseryl® in hastening udder tissue repair processes appeared to be dose dependent. The 200 mg dose of Solcoseryl® resulted in pre-endotoxin CMT scores as early as 6 days after endotoxin infusion.