| 端粒酶活性抑制研究进展 |
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| 引用本文： | 刘丹,汉丽梅,许大明. 端粒酶活性抑制研究进展[J]. 吉林畜牧兽医, 2006, 27(7): 15-18 |
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| 作者姓名： | 刘丹 汉丽梅 许大明 |
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| 作者单位： | 沈阳农业大学,辽宁,沈阳,110161;沈阳农业大学,辽宁,沈阳,110161;沈阳农业大学,辽宁,沈阳,110161 |
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| 摘 要： | 端粒酶是一种核糖蛋白,包括端粒酶RNA、端粒酶相关蛋白和端粒酶催化亚基三个主要组成部分,端粒和端粒酶具有特殊结构和功能,是近年来分子生物学研究的热点。端粒酶在85%～95%的恶性肿瘤中呈阳性,而正常体细胞则呈阴性,因此是一类潜在的高选择性的抗肿瘤药物,抑制剂的开发研究为恶性肿瘤的早期诊断,预后估计和基因治疗开辟了新的道路。
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| 关 键 词： | 端粒 端粒酶 端粒酶抑制剂 肿瘤 |
| 文章编号： | 1672-2078（2006）07-0015-04 |
| 收稿时间： | 2006-04-11 |
The Progress of Research about Inhibition of Telomerase Activity |
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| LIU Dan,HAN Li-mei,XU Da-ming. The Progress of Research about Inhibition of Telomerase Activity[J]. Jilin Animal Science and Veterinary Medicine, 2006, 27(7): 15-18 |
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| Authors: | LIU Dan HAN Li-mei XU Da-ming |
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| Affiliation: | Shenyang Agricultural University, Shenyang Liaoning 110161 |
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| Abstract: | telomerase is a nucleoglucoprotein which include telomerase RNA,telomerase associated protein and telomerase catalytic subunit, three main ingredient, telomere and telomerase which have special structure and function, are the hot spot of molecular biology research lately. Telomerase is masculine in 85% - 95% malignant tumor, but negative in normal body cell, so is a potential high-selective anti-tumor drug, development and research oftelomerase inhibitor pave a new way for early diagnosis of malignant tumor, prognosis estimation and gene therapy. |
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| Keywords: | telomere telomerase telomerase inhibitor tumor. |
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