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Diffuse bronchiolo-alveolar carcinoma in a dog
Authors:W Bertazzolo    D Zuliani  E Pogliani  M Caniatti  † C Bussadori  
Institution:Pronto Soccorso Veterinario -Lodi, Via Defendente, 29/A - 26900 Lodi, Italy;Pronto Soccorso Veterinario Viale Tibaldi, Viale Tibaldi 66, 20136 Milan, Italy;Istituto di Anatomia Patologica Veterinaria e Patologia Aviare, Universitàdegli Studi di Milano, Via Celoria 10, 20123 Milan, Italy;Clinica Veterinaria Gran Sasso, Via Donatello 26, 20131 Milan, Italy
Abstract:An eight-year-old female German wirehaired pointer was presented with signs of respiratory distress. Clinical examination, laboratory results, thoracic radiography and echocardiography indicated the presence of a diffuse interstitial lung disease with secondary appropriate erythrocytosis, pulmonary hypertension and cor pulmonale. Transthoracic fine needle aspiration biopsy of the lung suggested malignant epithelial neoplasia. A primary lung cancer with an unusually diffuse distribution of miliary/micronodular lesions was found at postmortem examination. Histological diagnosis was bronchiolo-alveolar carcinoma. Bronchiolo-alveolar carcinoma can occasionally occur in a diffuse fashion involving most or all of the lung parenchyma. In man, diffuse bronchiolo-alveolar carcinoma is considered a great imitator of other, more common diffuse interstitial forms of lung disease. This case report indicates that it is also a differential diagnosis to consider in dogs.
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