Use of metoprolol in dogs with acquired cardiac disease |
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| Authors: | John E Rush DVM MS Lisa M Freeman DVM PhD Cari Hiler DVM Donald J Brown DVM PhD |
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| Institution: | 1. Division of Cardiology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zürich, Switzerland;2. Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, via Tolara di Sopra 50, 40064 Ozzano Emilia (BO), Italy;1. Cardiology Department, Clinica Veterinaria Malpensa - AniCura, Viale Marconi 27, Samarate, Varese, 21017, Italy;2. Cardiology Department, Ospedale Veterinario I Portoni Rossi - AniCura, Via Roma 57, Zola Predosa, Bologna, 40069, Italy;3. Department of Clinical Sciences, Cornell College of Veterinary Medicine, Ithaca, NY, 14853-6401, USA;1. Red Bank Veterinary Hospital, 197 Hance Avenue, Tinton Falls, NJ, USA;2. Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 East Campus Drive, Columbia, MO 65211, USA;1. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA;2. Université Paris-Est, Ecole Nationale Vétérinaire d''Alfort, Unité de Cardiologie d''Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d''Alfort (CHUVA), 7 avenue du general de Gaulle, 94704 Maisons-Alfort cedex, France |
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| Abstract: | ObjectivesTo evaluate the response to metoprolol in dogs with dilated cardiomyopathy or endocardiosis receiving standard therapies for management of heart disease.BackgroundBeta-blocker therapy has been documented to improve survival in human patients with heart disease and heart failure. There are few studies documenting the effects of beta-blockers in dogs with naturally occurring heart disease.MethodsA retrospective study of medical records of dogs treated with metoprolol between 1991 and May 2000.ResultsEighty-seven dogs were treated with metoprolol between 1991 and May 2000. The majority of dogs tolerated the addition of metoprolol in a step-wise fashion. Side effects included syncope, congestive heart failure, lethargy, anorexia, weakness and diarrhea. Side effects were not more likely in dogs with pre-existing congestive heart failure.ConclusionsMetoprolol was well tolerated in the majority of dogs with naturally occurring dilated cardiomyopathy or endocardiosis. Further studies are required to determine if the administration of metoprolol is beneficial for this patient population. |
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| Keywords: | Metoprolol dilated cardiomyopathy endocardiosis heart failure beta-blocker |
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