The non-absorption of chloramphenicol after oral administration in adult ruminants: a tentative explanation from in vitro studies |
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| Authors: | K DE CORTE-BAETEN M DEBACKERE |
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| Institution: | Laboratorium voor Farmacologie en Toxicologie van de Huisdieren, (Directeur: Prof. Dr M. Debackere), Faculteit Diergeneeskunde, Rijksuniversiteit Gent, Casinoplein 24, B-9000 Gent, Belgium |
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| Abstract: | The biotransformation of chloramphenicol in the ruminant forestomachs was studied by incubating the antibiotic with ovine rumen contents in vitro. Differential centrifugation of rumen contents showed that rapid reduction of the aromatic nitro group of chloramphenicol to an arylamine occurred in those fractions containing ciliates, and this activity was not inhibited by penicillin or streptomycin. It is concluded that in adult ruminants, chloramphenicol is metabolised by rumen microfauna more rapidly than it is absorbed, when administered orally. |
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