Combined hepatocellular and cholangiocellular carcinoma in a dog |
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Authors: | Shiga A Shirota K Enomoto M |
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Institution: | Department of Veterinary Pathology, Azabu University, Sagamihara, Kanagawa, Japan. |
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Abstract: | A transitional type of combined hepatocellular and cholangiocellular carcinoma developed in a 12-year-old male Yorkshire terrier dog. The tumor was histologically composed of both hepatocellular carcinoma and cholangiocellular carcinoma components, and both elements were closely intermingled. Intraluminal mucin accumulation in cytokeratin-positive tubular/glandular structures was observed within the cholangiocellular carcinoma components and this feature was useful histological marker for a differential diagnosis between combined hepatocellular and cholangiocellular carcinoma and a pseudoglandular type of hepatocellular carcinoma. This primary hepatic tumor is extremely rare in dogs. |
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