Alpha-bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin |
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| Authors: | Tsai Ying-Chieh Hsu Hui-Chun Yang Wen-Chia Tsai Wei-Jern Chen Chien-Chih Watanabe Takashi |
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| Institution: | Institute of Biochemistry and Molecular Biology National Yang-Ming University, Taipei, Taiwan. tsaiyc@ym.edu.tw |
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| Abstract: | Steam distilled essential oil from the aerial parts of Pogostemon cablin was analyzed by gas chromatography-mass spectrometry (GC-MS). Forty one compounds were identified of which alpha-guaiene (20.62%) and alpha-bulnesene (16.18%) were major constituents. Furthermore, fractionation of the essential oil from P. cablin guided by inhibitory activity against PAF-induced platelet aggregation led to the isolation of the sesquiterpene, alpha-bulnesene. |
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| Keywords: | Essential oil Pogostemon cablin Platelet-activating factor (PAF) |
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