The fate and tissue disposition of deoxynivalenol in broiler
chickens |
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| Authors: | Sasithorn PRALATNET Saranya POAPOLATHEP Kanjana IMSILP Phanwimol TANHAN Supaporn ISARIYODOM Susumu KUMAGAI Amnart POAPOLATHEP |
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| Affiliation: | 1)Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand;2)Department of Animal Science, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand;3)Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113–8657, Japan |
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| Abstract: | To evaluate the fate of deoxynivalenol (DON) in broilers, DON was administered eitherintravenously or orally to broilers at a dose of 1 mg/kg BW. Concentrations of DON inplasma were measurable up to 4 hr and 2 hr after intravenous and oral administration,respectively. Following intravenous administration, the values for the eliminationhalf-life, the volume of distribution and the clearance were 1.25 ± 0.25 hr, 7.55 ± 2.03l/kg and 4.16 ± 0.42 l/hr/kg, respectively. The oralbioavailability was 15.46 ± 4.02%. DON was detectable in all tissues examined after oraladministration. These results suggest that DON is able to penetrate into the varioustissues in broilers, though poorly absorbed from their gastrointestinal tract. |
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| Keywords: | broiler deoxynivalenol fate residue residue broilers |
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