Concentrations of trimethoprim and sulphadoxine in tissues from goats and a cow. |
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| Authors: | P Nielsen F Rasmussen |
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| Institution: | Department of Pharmacology and Toxicology, Royal Veterinary and Agricultural University, Bülowsvej 13, Copenhagen V, DK-1870 Copenhagen, Denmark |
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| Abstract: | The concentration of trimethoprim and sulphadoxine in plasma and tissue from goats and a cow have been determined after a single intravenous injection. Furthermore, the concentration of the two drugs and their metabolites in plasma and tissues have been determined after continuous intravenous infusion for 2½–3 hrs. Trimethoprim was present in all tissues but brain at higher concentrations than in plasma while the concentration of sulphadoxine in the different tissues were lower than in plasma. The highest concentration of the 2 drugs and their metabolites was found in the kidney. The distribution pattern of trimethoprim and sulphadoxine was similar in cow and goats. |
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| Keywords: | trimethoprim sulphadoxine tissue concentrations |
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