Characterisation of the third component of canine and feline complement |
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Authors: | NT Gorman I McConnell PJ Lachmann |
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Institution: | Mechanisms in Tumour Immunity Unit, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, England. |
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Abstract: | Canine and feline C3 have been found by immune precipitation to have a molecular weight of 198K and 197K respectively. Each comprises two polypeptide chains α and β (canine α - 126K β - 72K; feline α - 125K β - 72K). The α chain is subsequently cleaved by C3b ina to produce two fragments αedc (canine 65K; feline 64K) and αfb (canine 40K; feline 46K). The findings are compared to the documented molecular structure of human C3. |
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