| Analysis on Sustained Release of Protein from Microcapsule Prepared by Alginate |
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| 作者姓名： | JIA Yun DAI Chuan-yun ZHAO Hong-wei LIU Huo-an |
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| 作者单位： | 1. College of Chemistry and Biology, Chongqing Polytechnic College, Chongqing 400050, China; 2. College of Bioengineering, Chongqing University, Chongqing 400030, China |
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| 摘 要： | The paper studies a drug deliversy system for protein and find the optimum preparation condition.Cross-linked alginate(Alg) microcapsule was used to prepare microcapsule for protein,using bovine serum album(BSA) as a model drug.Effect of different cations and content of protein on configuration,size and enveloped rate of microcapsule were investigated.It is shown that Ba-Alg microcapsule has steady configuration,homogeneous size and high-enveloped rate.Also electrophoresis of native BSA before microencapsulation and after microencapsulation is measured by(SDS-PAGE),it is found that no significant change is observed BSA integrity.Release of BSA from microcapsule in vitro presents sustained release in some extent,and initial burst effect is significantly obvious.Microenpsulation drug in alginate will be a wishful drug delivery system.
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| 关 键 词： | alginate miemeapsule protein sustained release |
| 收稿时间： | 2005/6/20 0:00:00 |
| 修稿时间： | 2005/6/20 0:00:00 |
Analysis on Sustained Release of Protein from Microcapsule Prepared by Alginate |
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| JIA Yun,DAI Chuan-yun,ZHAO Hong-wei,LIU Huo-an.Analysis on Sustained Release of Protein from Microcapsule Prepared by Alginate[J].Storage & Process,2005(10):108-110. |
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| Authors: | JIA Yun DAI Chuan-yun ZHAO Hong-wei LIU Huo-an |
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| Institution: | 1. College of Chemistry and Biology, Chongqing Polytechnic College, Chongqing 400050, China; 2. College of Bioengineering, Chongqing University, Chongqing 400030, China |
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| Abstract: | The paper studies a drug deliversy system for protein and find the optimum preparation condition.Cross-linked alginate(Alg) microcapsule was used to prepare microcapsule for protein,using bovine serum album(BSA) as a model drug.Effect of different cations and content of protein on configuration,size and enveloped rate of microcapsule were investigated.It is shown that Ba-Alg microcapsule has steady configuration,homogeneous size and high-enveloped rate.Also electrophoresis of native BSA before microencapsulation and after microencapsulation is measured by(SDS-PAGE),it is found that no significant change is observed BSA integrity.Release of BSA from microcapsule in vitro presents sustained release in some extent,and initial burst effect is significantly obvious.Microenpsulation drug in alginate will be a wishful drug delivery system. |
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| Keywords: | alginate miemeapsule protein sustained release |
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