氟虫腈/β-环糊精衍生物/壳聚糖纳米微球的制备及性能

本研究首先将β-环糊精 (β-CD) 进行修饰，以水难溶性氟虫腈 (FP) 为模型农药，制备了以羧甲基-β-环糊精 (CM-β-CD) 和羧甲基-羟丙基-β-环糊精 (CM-HP-β-CD) 为载体的FP包合物 (ICs)，然后ICs与壳聚糖 (CS) 通过静电相互作用形成纳米微球 (NPs)，并对纳米微球进行了表征。同时考察了包合物的溶解度、纳米微球的储存稳定性及光稳定性、体外释放行为。结果表明，FP经CM-β-CD和CM-HP-β-CD作用后可形成1 : 1的包合物，在水中的溶解度分别提高了102.34和76.29倍。载药纳米微球外观呈规则球形，粒径分布在200 nm左右，包封率最高可达90.42%。紫外光照射48 h后，2种纳米微球药物降解率均小于30%，明显低于FP原药的降解率 (88.8%)。从释放曲线得知纳米微球中的FP具有缓释性能，且释放符合Korsmeyer-Peppas模型，并在偏碱性条件下具有更高的释放率，这有助于提高对消化液偏碱性虫类的杀虫效果。

Formulation development and characterization of cefazolin nanoparticles-loaded cross-linked films of sodium alginate and pectin as wound dressings

In this study, β-cyclodextrin (β-CD) was modified and fipronil (FP) was used as a model pesticide, the inclusion complex (ICs) of carboxymethyl-β-cyclodextrin (CM-β-CD) and carboxymethyl-hydroxypropyl-β-cyclodextrin (CM-HP-β-CD) was prepared, then IC_S and chitosan (CS) were interacted with each other to form nanoparticles (NPs) via electrostatic interaction, and the NP_S were characterized. At the same time, the solubility of inclusion complex, the storage stability and light stability of nano-microspheres, and the release behavior in vitro were investigated. The results showed that FP formed 1:1 inclusion complexes with CM-β-CD and CM-HP-β-CD, increasing its solubility in water by 102.34 and 76.29 times, respectively. The drug-loaded nano-microspheres have a regular spherical appearance, the particle size distribution is about 200 nm, and the encapsulation efficiency can reach up to 90.42%. After UV irradiation for 48 h, the degradation rate of both nanoparticles was less than 30%, which was significantly lower than that of FP (88.8%). The release profiles showed the NPs provided sustained release of FP, following the Korsmeyer-Peppas model. The NPs also exhibited a higher release rate under alkaline conditions, which could help improve insecticidal efficacy of alkaline insects in the digestive juice.